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Figure 4 | BMC Medicine

Figure 4

From: The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder

Figure 4

Network analysis performed on converging genes differentially regulated in response to different stresses in mouse and between different selected Flinders lines. The pathway comprises over half the reference molecules uploaded to the Ingenuity database system (12 out of the 21 reference molecules). The pathway implicates a number of genes previously associated with MDD and antidepressant treatment response, including Ppm1a, Ywhaz, NkFb and Mapk.

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