The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder

Table 3 Convergent genes across all rodent studies

Probe Set ID	Gene symbol	RP/Rsum	*PFP*	P-value
1034_at	TIMP3	10.3564	1.0512	0.6398
1035_g_at	TIMP3	10.788	0.9069	0.7097
1235_at	YWHAZ	8.1361	1.8677	0.2436
2018_at	GJA1	10.6102	0.9224	0.6818
296_at	TUBB2A	8.1718	1.4332	0.2493
297_g_at	TUBB2A	10.38	0.9872	0.6438
32254_at	VAMP2	9.7002	0.0024	0.5228
32531_at	GJA1	5.6354	0.4128	0.018
32572_at	USP9X	9.6037	1.0556	0.5049
32761_at	SRRM2	11.6727	0.9074	0.8285
34387_at	LPGAT1	10.5963	0.9769	0.6796
34642_at	YWHAZ	6.7492	0.8804	0.0766
36307_at	ARC	8.5526	1.0273	0.3127
36760_at	YWHAZ	9.8422	0.9712	0.5489
38211_at	ZBTB20	8.6008	0.8204	0.321
38710_at	OTUB1	9.566	1.145	0.4978
39331_at	TUBB2A	8.2579	1.2097	0.263
39725_at	RBM39	10.946	0.888	0.7336
40096_at	ATP5A1	8.5727	0.9088	0.3161
40125_at	CANX	8.2587	1.0086	0.2631
968_i_at	USP9X	11.0827	0.8662	0.7532

The expression profile of these genes is tagged by 21 probe sets. Expression differences between cases and control were evaluated using the RankProd algorithm using probability of false positive (PFP) of less the 0.05 to control for the number of multiple testing. The table shows Probe Set ID, Gene Symbol, RankProd value, corrected PFP value and uncorrected -value. The only gene that survives correction for multiple testing in the human analysis is the VAMP-2 gene.

ISSN: 1741-7015