Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

Table 2 Cox proportional hazard ratios for total mortality according to quintiles of cumulative total polyphenol intake

	Quintiles of cumulative intake of total polyphenols, mg/d
	Q1 (535)	Q2 (700)	Q3 (800)	Q4 (917)	Q5 (1170)	P- trend
No. of deaths	88	62	52	63	62
No. of person-years	5,505	6,599	6,767	6,559	5,638
Age- and sex-adjusted HR (95% CI)^*	1.00	0.65 (0.44 to 0.95)	0.55 (0.37 to 0.82)	0.73 (0.50 to 1.06)	0.66 (0.44 to 0.98)	0.12
Multivariable-adjusted HR (95% CI)^†	1.00	0.68 (0.46 to 1.01)	0.60 (0.39 to 0.90)	0.75 (0.51 to 1.12)	0.60 (0.39 to 0.91)	0.07
Additionally adjusted HR (95% CI)^‡	1.00	0.71 (0.48 to 1.05)	0.62 (0.41 to 0.95)	0.79 (0.53 to 1.17)	0.63 (0.41 to 0.97)	0.12

HR, Hazard ratio; CI, Confidence interval.
^*Analyses were stratified by sex, recruitment center and intervention group.
^†The multivariable HR has been additionally adjusted for age (<60, 60 to 64.9, 65 to 69.9, 70 to 74.9, >/=75 years), smoking (never, past and current: cigarettes (<5, 5 to 19, >20 per day) or cigars and pipes (<3, 3 to 6, >6 per day)), BMI (<25, 25 to 29.9, or >/=30 Kg/m²), baseline diabetes, alcohol (0, 0.1 to 14.9, 15 to 29.9, >/=30 g/day), total energy intake (continuous variable), physical activity (continuous variable), family history of CVD or cancer, aspirin use, antihypertensive drug use, use of cardiovascular medication, use of oral hypoglycaemic agents, insulin, other medication.
^‡This model has been additionally adjusted for intake of protein, saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids and cholesterol (all as continuous variables).

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