Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

Table 3 HR for total mortality according to quintiles of total polyphenol intake (stratified by risk factors)

Risk factor	No. of deaths	No. of person-years	Multivariable-adjusted HR (95% CI), Quintile 5 vs. 1^*	P-trend	P-interaction
Sex
Men	203	13,317	0.76 (0.46 to 1.26)	0.23	0.39
Women	124	17,751	0.42 (0.18 to 0.98)	0.24
Age, y
<70	142	21,483	0.58 (0.31 to 1.08)	0.21	0.73
≥70	185	9,585	0.70 (0.39 to 1.24)	0.34
Alcohol intake
Nondrinkers	133	12,510	0.39 (0.17 to 0.90)	0.04	0.16
Drinkers	194	18,558	0.99 (0.59 to 1.65)	0.91
Smoking
Never	144	19,520	0.64 (0.31 to 1.32)	0.47	0.93
Former	111	7,465	0.52 (0.25 to 1.07)	0.29
Current	72	4,083	0.71 (0.29 to 1.75)	0.21
Physical activity
Less than median	203	16,224	0.57 (0.32 to 1.02)	0.17	0.43
More than median	124	14,844	0.77 (0.41 to 1.44)	0.73
Hypertension
Yes	184	12,080	0.63 (0.36 to 1.10)	0.24	0.21
No	134	17,721	0.82 (0.44 to 1.55)	0.76
Diabetes mellitus
Yes	205	15,345	0.79 (0.47 to 1.33)	0.92	0.52
No	122	15,723	0.60 (0.31 to 1.17)	0.09
Intervention group
MedDiet-EVOO	113	11,478	0.67 (0.31 to 1.46)	0.68	0.71
MedDiet-Nuts	108	10,134	0.68 (0.34 to 1.35)	0.81
Control Diet	106	9,456	0.48 (0.23 to 0.98)	0.01

HR, Hazard ratio; CI, Confidence interval; MedDiet-EVOO, Mediterranean Diet supplemented with extra virgin olive oil; MedDiet-nuts, Mediterranean Diet supplemented with nuts.
^*The multivariable HR has been additionally adjusted for age (<60, 60to 4.9, 65 to 69.9, 70 to 74.9, >/=75 years), smoking (never, past and current: cigarettes (<5, 5 to 19, >20 per day) or cigars and pipes (<3, 3 to 6, >6 per day)), BMI (<25, 25 to 29.9, or >/=30 Kg/m²), baseline diabetes, alcohol (0, 0.1 to 14.9, 15 to 29.9, >/=30 g/day), total energy intake (continuous variable), physical activity (continuous variable), family history of CVD or cancer, aspirin use, antihypertensive drug use, use of cardiovascular medication, use of oral hypoglycemic agents, insulin, other medication. Analyses were stratified by sex, recruitment center and intervention group.

ISSN: 1741-7015