Unadjusted | Adjusteda | |||||
---|---|---|---|---|---|---|
hazard ratio (95% CI) | hazard ratio (95% CI) | |||||
3 months | First year | Total study period | 3 months | First year | Total study period | |
Quartiles | ||||||
Quartile 1 (ref.) <5.2 pmol/L | 1 | 1 | 1 | 1 | 1 | 1 |
Quartile 2 5.2-10.5 pmol/L | 1.10 (0.47-2.59) | 1.33 (0.79-2.24) | 1.39 (1.13-1.70) | 0.70 (0.29-1.69) | 0.87 (0.50-1.50) | 1.01 (0.81-1.26) |
Quartile 3 10.5-24.1 pmol/L | 2.66 (1.28-5.52) | 2.53 (1.58-4.04) | 2.14 (1.76-2.61) | 1.40 (0.66-2.96) | 1.27 (0.74-2.08) | 1.21 (0.98-1.51) |
Quartile 4 >24.1 pmol/L | 7.40 (3.80-14.39) | 5.62 (3.65-8.66) | 3.52 (2.91-4.27) | 2.48 (1.19-5.15) | 1.95 (1.20-3.17) | 1.65 (1.33-2.06) |
Elevated copeptin (>11.3 pmol/L) | ||||||
Normal copeptin (ref.) | 1 | 1 | 1 | 1 | 1 | 1 |
Elevated copeptin | 4.90 (3.08-7.81) | 3.61 (2.70-4.85) | 2.28 (2.00-2.60) | 2.44 (1.47-4.08) | 1.85 (1.33-2.58) | 1.36 (1.17-1.57) |
95%-percentile vs. 5%-percentile | ||||||
5%-percentile (ref.) <2.4 pmol/L | 1 | 1 | 1 | 1 | 1 | 1 |
95%-percentile | 40.43 (5.51-296.90) | 29.36 (7.07-121.99) | 5.41 (5.53-8.29) | 7.09 (0.92-54.86) | 4.99 (1.16-21.50) | 1.60 (1.00-2.58) |
Per 1 increase in log copeptin | 6.66 (4.63-9.57) | 4.24 (3.29-5.47) | 2.76 (2.41-3.15) | 3.24 (2.07-5.08) | 1.96 (1.43-2.68) | 1.52 (1.29-1.79) |