TY - JOUR AU - Edlund, Anna AU - Esguerra, Jonathan LS AU - Wendt, Anna AU - Flodström-Tullberg, Malin AU - Eliasson, Lena PY - 2014 DA - 2014/05/28 TI - CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells JO - BMC Medicine SP - 87 VL - 12 IS - 1 AB - Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF). Although patients with CF often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that CFTR has a biological function in pancreatic beta-cells. SN - 1741-7015 UR - https://doi.org/10.1186/1741-7015-12-87 DO - 10.1186/1741-7015-12-87 ID - Edlund2014 ER -