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Table 1 Genetic variants with evidence supporting clinical utility

From: Towards the clinical implementation of pharmacogenetics in bipolar disorder

Drug

Gene

Marker

Lithium

BDNF

rs6265

NTRK2

rs1387923

CREB1

rs6740584

GRIA2

rs9784453

GSK3B

rs1954787

Carbamazepine

HLA

rs2844682; rs3909184

Antipsychotics

DRD2

rs1799732

HTR2A

rs6311

ANNK1

rs1800497

HTR2C

rs3813929

SSRI’s

GRIK4

rs1954787

HTR2A

rs7997012

SLC6A4

5-HTTLPR

rs25531

Drug Metabolism

CYP2D6

Multiple markers [124–126]

CYP2C19

Multiple markers [115, 151–153]

  1. SSRI’s, selective serotonin receptor inhibitors.