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Table 2 Genetic markers associated with mood stabilizer outcomes

From: Towards the clinical implementation of pharmacogenetics in bipolar disorder

Drug/Phenotype

Gene

Marker

Subjects

Studies

Diagnosis

Phenotype association

Level of evidence

Lithium

BDNF

rs6265

538

3

BD I/II

A(Met)-allele associated with better response

1

NTRK2

rs1387923

284

1

BDI

T-allele associated with better response

2

CREB1

rs6740584

258

1

BD I/II

GA genotype associated with better response

2

GRIA2

rs9784453

817

2

BD I/II

A-allele associated with worse response

1

ODZ4

rs11237637

817

2

BD I/II

T-allele associated with worse response

1

GSK3B

rs1954787

307

3

BD I

C-allele associated with better response

2

Carbamazepine

HLA

HLA-B*1502

380

2

Unspecified

HLA-B*1502 associated with SJS/TEN

2

  1. BD, bipolar disorder; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis.