From: Towards the clinical implementation of pharmacogenetics in bipolar disorder
Drug/Phenotype | Gene | Marker | Subjects | Studies | Diagnosis | Phenotype association | Level of evidence |
---|---|---|---|---|---|---|---|
Lithium | BDNF | rs6265 | 538 | 3 | BD I/II | A(Met)-allele associated with better response | 1 |
NTRK2 | rs1387923 | 284 | 1 | BDI | T-allele associated with better response | 2 | |
CREB1 | rs6740584 | 258 | 1 | BD I/II | GA genotype associated with better response | 2 | |
GRIA2 | rs9784453 | 817 | 2 | BD I/II | A-allele associated with worse response | 1 | |
ODZ4 | rs11237637 | 817 | 2 | BD I/II | T-allele associated with worse response | 1 | |
GSK3B | rs1954787 | 307 | 3 | BD I | C-allele associated with better response | 2 | |
Carbamazepine | HLA | HLA-B*1502 | 380 | 2 | Unspecified | HLA-B*1502 associated with SJS/TEN | 2 |