Towards the clinical implementation of pharmacogenetics in bipolar disorder

Table 3 Genetic markers associated with antipsychotics outcomes

Drug/Phenotype	Gene	Marker	Subjects	Studies	Diagnosis	Phenotypic association	Level of evidence
Antipsychotics	DRD2	rs1799732	687	6^a	Schizophrenia	Del-allele associated with poor response	1
	HTR2A	rs6311	315	2	Schizophrenia	A-allele associated with good response	2
	ANNK1	rs1800497	1,256	6^a	Schizophrenia	A2-allele associated with TD risk	1
	HTR2C	rs3813929	1,108	14^a	Schizophrenia	C-allele associated with weight gain	1
	MC4R	rs489693	344	4	Unspecified	AA genotype associated with weight gain	2
	MC4R	rs17782313	345	1	Multiple	C-allele associated with weight gain	2

ISSN: 1741-7015