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Table 2 Efficacy of lidocaine delivery to tissues through four microconduits.

From: Transdermal microconduits by microscission for drug delivery and sample acquisition

Site treatment Four microconduits, soaked with lidocaine for 5 minutes Sensation description (at two laser powers)
  35 mJ 40 mJ
15 min after lidocaine   
Control – no lidocaine, no microconduit Sharp interior pain Sharp interior, very painful
Control – lidocaine, no microconduit Sharp interior pain Sharp interior, very painful
lidocaine microconduit site Hardly perceptible Hardly perceptible
30 min after lidocaine   
Repeat 15 minute test sequence No changes in sensation levels
75 min after lidocaine   
Control – no lidocaine, no microconduit Sharp interior pain Sharp interior, very painful
Control – lidocaine, no microconduit Sharp interior pain Sharp interior, very painful
lidocaine microconduit site Considerable pain Sharp interior pain