Table 2 Efficacy of lidocaine delivery to tissues through four microconduits.
From: Transdermal microconduits by microscission for drug delivery and sample acquisition
Site treatment Four microconduits, soaked with lidocaine for 5 minutes | Sensation description (at two laser powers) | |
|---|---|---|
35 mJ | 40 mJ | |
15 min after lidocaine | ||
Control – no lidocaine, no microconduit | Sharp interior pain | Sharp interior, very painful |
Control – lidocaine, no microconduit | Sharp interior pain | Sharp interior, very painful |
lidocaine microconduit site | Hardly perceptible | Hardly perceptible |
30 min after lidocaine | ||
Repeat 15 minute test sequence | No changes in sensation levels | |
75 min after lidocaine | ||
Control – no lidocaine, no microconduit | Sharp interior pain | Sharp interior, very painful |
Control – lidocaine, no microconduit | Sharp interior pain | Sharp interior, very painful |
lidocaine microconduit site | Considerable pain | Sharp interior pain |