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Table 2 Secretory (bisolateral to apical) Michaelis-Menten constant (K m), carrier permeability (P c) and passive permeability (P m) for transport of 20-(S)-camptothecin (CPT) across Caco-2 cells, MDCK II/wild type (wt) cells, MDCK II/P-glycoprotein (PGP) cells and MDCK II/Multidrug Resistance Protein 2 (MRP2) cells

From: Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

 

Bisolateral to apical

 

Caco-2

MDCK II/wt

MDCK II/PGP

MDCK II/MRP2

K m (μM)

132.9 ± 12.2

81.3 ± 14.6

36.3 ± 7.5

65.8 ± 6.7

P c (cm/s × 105)

2.1 ± 0.1

2.0 ± 0.2

4.1 ± 0.4

4.3 ± 0.7

P m (cm/s × 105)

0.35 ± 0.04a

Not determined

Not determined

Not determined

  1. Results reported as the mean ± standard deviation. a P m was estimated as the efflux P eff of CPT at 4°C.
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BMC Medicine

ISSN: 1741-7015

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