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Table 1 Frequency and type of H-Ras mutations in MMTV-Wnt1 tumors

From: Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype

 

Codon mutated

Number (% total)

Activating H-Ras mutations

CAA61CTA

10 (22%)

 

GGA12GAA

5 (11%)

 

CAA61CGA

4 (9%)

 

CAA61AAA

2 (4%)

 

CAA61CAT

1 (2%)

 

GGC13AGA

1 (2%)

 

GGC13GTT

1 (2%)

H-Ras WT

 

22 (48%)

Total

 

46 (100%)

  1. Primary tumor cDNA was amplified and sequenced with H-Ras-specific primers at least once in each direction as described in Methods. Products containing mutant peaks equal to or greater in height than the wild type peaks in at least one sequencing direction were scored as mutation-positive. Mutations in codons 12,13, 59, and 61 were scored as activating mutations.