|
MMTV-Wnt1/p53
+/-
|
MMTV-Wnt1/p53
-/-
|
MMTV-Wnt1/MMTV-Neu
|
---|
With H-Ras mutations
|
5 (2 with p53 LOH)
|
0
|
0
|
Without H-Ras mutations
|
6 (3 with p53 LOH)
|
16
|
11
|
Total
|
11 (5 with p53 LOH)
|
16
|
11
|
- Primary tumor cDNAs (11 MMTV-Wnt1/p53
-/- samples) or DNAs (5 MMTV-Wnt1/p53
-/- samples and all of the MMTV-Wnt1/p53+/- samples) were amplified and sequenced with H-Ras-specific primers at least once in each direction, as described in Methods. Mutations were scored by the same criteria described in Table 1.