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Table 2 Comparison of 50% antiviral and cell division inhibitory concentrations (IC50) and selectivity (viral versus cellular IC50) of selected antiviral drugs and THC

From: Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro

Inhibitor compound KSHV IC50 (μM) Cellular IC50 (μM) Selectivity index (viral versus cellular IC50)
Acyclovir 75 [ref. 32] Not done  
Ganciclovir 5.1 [ref. 32] Not done  
Foscarnet 97 [ref. 32] Not done  
Cidofovir 0.05 [ref. 32] Not done  
THC 3.3 (this work) 33 (this work) 10 (this work)
  MHV 68 IC 50 (μM)   
Acyclovir 6 [ref. 34]
100 [ref. 33]
182 [ref. 34] 30 [ref. 34]
Ganciclovir 28 [ref. 34] 108 [ref. 34] 3.7 [ref. 34]
Foscarnet 120 [ref. 34] 1413 [ref. 34] 11 [ref. 34]
Cidofovir 0.08 [ref. 34] 78 [ref. 34] 10,000 [ref. 34]
THC 1.9 (this work) 99 (this work) 52 (this work)