|
Plasma (mg/dL)
|
|---|
|
Group
|
Cholesterol
|
Campesterol
|
Stigmasterol
|
β-Sitosterol
|
|
Abcg8+/+
|
73.0 ± 14
|
1.1 ± 0.7
|
ND
|
0.5 ± 0.5
|
|
Abcg8+/-
|
54.0 ± 10*
|
1.8 ± 0.3*
|
ND
|
0.8 ± 0.2*
|
|
Abcg8-/-
|
35.0 ± 6.0*
|
8.8 ± 2.1*
|
ND
|
18.5 ± 5.0*
|
|
Liver (μg/g wet tissue)
|
|
Group
|
Cholesterol
|
Campesterol
|
Stigmasterol
|
β-Sitosterol
|
|
Abcg8+/+
|
2280 ± 310
|
52.2 ± 15.0
|
ND
|
16.7 ± 8.6
|
|
Abcg8+/-
|
2460 ± 588
|
76.4 ± 12.3*
|
1.6 ± 3.3*
|
26.7 ± 6.4*
|
|
Abcg8-/-
|
1202 ± 264*
|
233.9 ± 48.1*
|
22.7 ± 6.3*
|
376.3 ± 91.6*
|
|
Spleen (μg/g wet tissue)
|
|
Group
|
Cholesterol
|
Campesterol
|
Stigmasterol
|
β-Sitosterol
|
|
Abcg8+/+
|
2702 ± 310
|
41.7 ± 7.6
|
15.1 ± 14.1
|
21.9 ± 10.9
|
|
Abcg8+/-
|
2578 ± 320
|
66.8 ± 18.8*
|
14.5 ± 16.9*
|
32.2 ± 6.1*
|
|
Abcg8-/-
|
1779 ± 195*
|
353.8 ± 97.5*
|
ND*
|
436.6 ± 148.5*
|
|
Brain (μg/g wet tissue)
|
|
Group
|
Cholesterol
|
Plant sterols
|
Desmosterol
|
Lathosterol
|
|
Abcg8+/+
|
11301 ± 156
|
10.2 ± 3.9
|
102.0 ± 13.3
|
52.0 ± 0.3
|
|
Abcg8+/-
|
11846 ± 814
|
24.5 ± 5.5
|
113.7 ± 25.5
|
49.1 ± 4.2
|
|
Abcg8-/-
|
11846 ± 1061
|
63.0 ± 6.5
|
123 ± 18.3
|
56.9 ± 9.5
|
- Animals used in these studies were 12 weeks of age, a mixture of male and female and fed a regular chow diet. *P < 0.05 for -/- versus +/+ and -/- versus +/-. ND, not detectable.
