Figure 1

The association between S-digoxin levels and the number of prescribed P-gp inhibitors (A) Adjusted* S-digoxin means for the patients without ('0') (N = 328, S-digoxin mean ± SE 1.26 ± 0.04 nmol/L) or with ('≥ 1'), P-gp inhibitors (N = 290, S-digoxin mean ± SE 1.55 ± 0.04 nmol/L). (B) Adjusted* S-digoxin means for patients taking zero, one, two or three P-gp inhibitors. The number of patients were 328, 204, 78 and eight, respectively. The S-digoxin means ± SE (nmol/L) were 1.26 ± 0.04, 1.51 ± 0.05, 1.59 ± 0.08 and 2.00 ± 0.25. *Adjusted for age, sex, digoxin dose and total number of prescribed drugs.