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Table 2 Drug classification

From: Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Class I substance No. of patients using the drug References
Amiodarone 12 [21], [22]
Atorvastatin 12 [11], [20]
Cyclosporine A 3 [23]
Dipyridamole 12 [24]
Quinidine 1 [1], [25]
Quinine 1 [26], [27]
Spironolactone 106 [25]
Verapamil 31 [25]
Class II substance No. of patients using the drug References
Bromocriptine 1 [28]
Flupentixol 1 [29]
Glibenclamide 46 [30]
Isradipine 2 [21], [31]
Lansoprazole 51 [32]
Loperamide 2 [33], [34]
Medroxyprogesterone 2 [35]
Omeprazole 35 [32]
Pantoprazole 6 [32]
Paroxetine 6 [36]
Sertraline 29 [36], [37]
Simvastatin 17 [20]
Terfenadine 1 [38]
  1. The coadministered drugs were classified for their effects on P-gp and on digoxin pharmacokinetics. Class I P-gp inhibitors have well-documented effects on digoxin pharmacokinetics in vivo, while Class II P-gp inhibitors have established P-gp inhibitory effects in vitro and putative effects on S-digoxin in vivo.
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BMC Medicine

ISSN: 1741-7015

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