Figure 5

Comparisons of large and small intestine age-related CSX methylation rates. Average percent methylation increased more slowly with age in the small intestine (black circles) relative to previously published [10, 17] colon measurements (red triangles). However this trend (black and red dotted lines) was not significant. A lower stem cell division rate was more consistent with the small intestinal data (green line, 0.75 divisions per day), relative to a model [10] postulating one division per day for the colon (grey line).