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Figure 7 | BMC Medicine

Figure 7

From: Age-related human small intestine methylation: evidence for stem cell niches

Figure 7

An intestinal tree based on mitotic ages or numbers of divisions since birth. Each horizontal branch reflects a single crypt. Although all tissues have the same chronological ages, differences in stem cell division rates allow tissues within the same individual to have different mitotic ages. A small intestine tree has a more crypt branches (greater numbers of crypts) than a colon, but its branches may be shorter, which can possibly help explain why despite the greater physical size of the organ, small intestinal tumors are infrequent relative to colonic ones.

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