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Table 1 Demographic and clinical characteristics at baseline for patients with a major depressive episode (full analysis set)

From: Superior efficacy of St John's wort extract WS®5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]

Characteristic   WS® 5570 600 mg/day N = 119 WS® 5570 1200 mg/day N = 124 Placebo N = 81 p-value
Sex:      0.13*
   Female n (%) 67 (56.3) 82 (66.1) 56 (69.1)  
   Male n (%) 52 (43.7) 42 (33.9) 25 (30.9)  
Age (years) Mean ± SD 46.3 ± 11.5 46.1 ± 10.7 46.9 ± 11.8 0.69§
HAM-D total score Mean ± SD 22.8 ± 3.3 22.6 ± 3.8 23.6 ± 4.2 0.31
CGI severity of illness:      0.20*
   Mildly or moderately ill n (%) 67 (56.3) 62 (50.0) 46 (56.8)  
   Markedly or severely ill n (%) 52 (43.7) 62 (50.0) 35 (43.2)  
MADRS Mean ± SD 27.2 ± 5.5 26.3 ± 6.0 28.0 ± 6.2 0.09§
BDI Mean ± SD 23.2 ± 7.9 23.3 ± 8.0 25.7 ± 8.9 0.05§
SF-36 summary measure mental health Mean ± SD 25.1 ± 11.7 27.7 ± 13.3 23.7 ± 11.1 0.16§
  1. For the HAM-D, MADRS and BDI, a higher value indicates more severe impairment whereas for the SF-36, a lower score indicates more severe impairment.
  2. *Two-sided chi-square test
  3. §Two-sided Kruskal-Wallis test