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Table 2 Comparison of HAM-D scores for patients with a major depressive episode over 6-week treatment with WS® 5570 or placebo (full analysis set; last observation carried forward)

From: Superior efficacy of St John's wort extract WS®5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]

HAM-D measure WS® 5570 600 mg/day N = 119 WS® 5570 1200 mg/day N = 124 Placebo N = 81 p-value
      WS® 5570 600 mg/day vs placebo WS® 5570 1200 mg/day vs placebo
Total score (mean ± SD) Day 0 22.8 ± 3.3 22.6 ± 3.8 23.6 ± 4.2 0.14 0.09
  Day 14 17.9 ± 6.3 18.2 ± 6.6 19.1 ± 20 0.23 0.34
  Day 42 11.2 ± 7.0 11.8 ± 8.3 17.6 ± 8.8 <0.001 <0.001
Difference vs day 0 (mean ± SD) Day 14 -4.9 ± 5.1 -4.5 ± 4.7 -4.5 ± 5.4 0.65 0.95
  Day 42 -11.6 ± 6.4 -10.8 ± 7.3 -6.0 ± 8.1 <0.001 <0.001
Mean reduction vs day 0 (%) Day 14 22.0% 20.9% 16.7% 0.54 0.77
  Day 42 57.9% 57.1% 16.7% <0.001 <0.001
Comparison vs placebo for difference day 42 vs day 0 WS ® 5570 600 mg/day vs placebo WS ® 5570 1200 mg/day vs placebo   
Differences in means* -5.6 -4.8   
95% confidence interval [-7.7, -3.6] [-6.9, -2.6]   
p-value <0.001 <0.001   
  1. *A negative difference denotes a more favorable outcome in the treatment group named first.