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Table 3 Relative decreases in HAM-D scores for subgroups of patients with a major depressive episode after 6 weeks of treatment with WS® 5570 or placebo (full analysis set, last observation carried forward)

From: Superior efficacy of St John's wort extract WS®5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]

Subgroup based on baseline score Mean % decrease ± SD, number of patients p-value
   WS® 5570 600 mg/day N = 119 WS® 5570 1200 mg/day N = 124 Placebo N = 81 WS® 5570 600 mg/day vs placebo WS® 5570 1200 mg/day vs placebo
Baseline HAM-D total score cutoff 20 (split at 25th percentile) <20 54.2 ± 26.3, 25 56.0 ± 29.9, 31 32.7 ± 40.5, 14 0.09 0.07
  ≥ 20 51.1 ± 28.3, 94 46.4 ± 32.5, 93 24.4 ± 33.6, 67 <0.001 <0.001
Baseline HAM-D total score cutoff 23 (split at median) <23 55.5 ± 28.1, 56 53.1 ± 29.7, 64 26.8 ± 38.8, 37 <0.001 <0.001
  ≥ 23 48.4 ± 27.4, 63 44.2 ± 33.9, 60 25.1 ± 31.4, 44 <0.001 <0.01
Baseline HAM-D total score cutoff 25 (split at 75th percentile) <25 53.6 ± 27.3, 83 52.8 ± 30.2, 85 28.6 ± 37.7, 49 <0.001 <0.001
  ≥ 25 47.4 ± 28.9, 36 40.2 ± 34.5, 39 21.7 ± 29.8, 32 <0.001 0.02
Baseline CGI item 1, severity of illness <5* 51.2 ± 28.7, 67 49.9 ± 31.5, 62 28.0 ± 36.1, 46 <0.001 <0.01
  ≥ 5§ 52.4 ± 26.9, 52 47.7 ± 32.7, 62 23.1 ± 33.3, 35 <0.001 <0.001
  1. * "Moderately ill or less severe"
  2. § "Markedly ill or more severe"