Superior efficacy of St John's wort extract WS®5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]

Table 3 Relative decreases in HAM-D scores for subgroups of patients with a major depressive episode after 6 weeks of treatment with WS^® 5570 or placebo (full analysis set, last observation carried forward)

Subgroup based on baseline score		Mean % decrease ± SD, number of patients			p-value
		WS^® 5570 600 mg/day N = 119	WS^® 5570 1200 mg/day N = 124	Placebo N = 81	WS^® 5570 600 mg/day vs placebo	WS^® 5570 1200 mg/day vs placebo
Baseline HAM-D total score cutoff 20 (split at 25^th percentile)	<20	54.2 ± 26.3, 25	56.0 ± 29.9, 31	32.7 ± 40.5, 14	0.09	0.07
	≥ 20	51.1 ± 28.3, 94	46.4 ± 32.5, 93	24.4 ± 33.6, 67	<0.001	<0.001
Baseline HAM-D total score cutoff 23 (split at median)	<23	55.5 ± 28.1, 56	53.1 ± 29.7, 64	26.8 ± 38.8, 37	<0.001	<0.001
	≥ 23	48.4 ± 27.4, 63	44.2 ± 33.9, 60	25.1 ± 31.4, 44	<0.001	<0.01
Baseline HAM-D total score cutoff 25 (split at 75^th percentile)	<25	53.6 ± 27.3, 83	52.8 ± 30.2, 85	28.6 ± 37.7, 49	<0.001	<0.001
	≥ 25	47.4 ± 28.9, 36	40.2 ± 34.5, 39	21.7 ± 29.8, 32	<0.001	0.02
Baseline CGI item 1, severity of illness	<5*	51.2 ± 28.7, 67	49.9 ± 31.5, 62	28.0 ± 36.1, 46	<0.001	<0.01
	≥ 5^§	52.4 ± 26.9, 52	47.7 ± 32.7, 62	23.1 ± 33.3, 35	<0.001	<0.001

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