Figure 4
Comparison with cell line experiments. Fold changes induced by estrogen and tamoxifen treated MCF-7 cell lines for unique genes that are down-regulated (n = 54) or up-regulated (n = 30) by HRT in breast cancer patients. The fold changes are shown on the log2 scale, so the dashed line at zero corresponds to no differential expression, positive values correspond to up-regulation in treated cells, and negative values correspond to down-regulation in treated cells compared with untreated control cells (see additional file 1 on fold change calculation and gene matching).