Grey matter changes can improve the prediction of schizophrenia in subjects at high risk

Table 1 Predictive statistics for schizophrenia using all 65 subjects.

Region	False+, False-	PPV%	NPV%	Likelihood ratio +	Likelihood ratio -	Sensitivity %	Specificity %	Effect size
Right cerebellum	7, 6	22	89	2.04	0.86	25	88	-0.82
Left uncus	4, 7	20	88	1.78	0.94	13	93	-0.33
Left inferior temporal gyrus	2, 5	60	92	10.69	0.65	38	96	-0.68

Statistics for the prediction of the development of schizophrenia within a 10-year period, based on changes in grey matter in the right cerebellum, left uncus and left inferior temporal gyrus (n = 65, all familial high-risk subjects with two scans in the first 4 years of the Edinburgh High Risk Study).
+ positive; - negative; NPV negative predictive value; PPV positive predictive value

ISSN: 1741-7015