Grey matter changes can improve the prediction of schizophrenia in subjects at high risk

Table 2 Predictive statistics for schizophrenia within those 18 subjects with minor symptoms.

Region	False+, False-	PPV%	NPV%	Likelihood ratio +	Likelihood ratio -	Sensitivity %	Specificity %	Effect size
Right cerebellum	2, 3	71	73	3.13	0.47	63	80	-0.68
Left uncus	3, 5	50	58	1.25	0.89	38	70	-0.09
Left inferior temporal gyrus	3, 3	63	70	2.08	0.54	63	70	-0.55

Statistics for the prediction of the development of schizophrenia within a 10-year period, based on changes in grey matter in the right cerebellum, left uncus and left inferior temporal gyrus (n = 18; only familial high-risk subjects who had transient, partial or isolated psychotic symptoms and had two scans in the first 4 years of the Edinburgh High Risk Study).
+ positive; - negative; NPV, negative predictive value; PPV, positive predictive value.

ISSN: 1741-7015