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Table 2 Effect estimates (odds ratios) for spina bifida-affected pregnancies associated with CHKA SNPs hCV1562388 (A>C) and hCV1562393(C>G), PCYT1A SNPs rs939883 (T>A) and rs3772109 (T>C), California 1989–1991. OR: odds ratio; aOR: adjusted odds ratio by maternal ethnicity; CI: confidence interval.

From: CHKA and PCYT1Agene polymorphisms, choline intake and spina bifida risk in a California population

CHKA gene Cases (%) Controls (%) OR (95% CI) aOR (95% CI)
SNP hCV1562388 (A>C)
AA 54 (54.0) 138 (41.2) Reference -
AC 38 (38.0) 154 (46.0) 0.63 (0.39–1.01) 0.62 (0.39–1.00)
CC 8 (8.0) 43 (12.8) 0.48 (0.21–1.08) 0.48 (0.21–1.10)
AC+CC 46 (46.0) 197 (58.8) 0.60 (0.38–0.94) 0.55(0.38–0.99)
SNP hCV1562393(C>G)
CC 66 (67.3) 225 (67.6) Reference -
CG+GG 32 (32.6) 108 (32.4) 0.99 (0.61–1.62) 1.01 (0.62–1.66)
PCYT1A gene Cases (%) Controls (%) OR (95% CI) aOR (95% CI)
SNP rs939883 (T>A)
TT 35 (34.3) 132 (39.9) Reference -
TA 48 (47.1) 161 (48.6) 1.12 (0.69–1.84) 1.14 (0.70–1.87)
AA 19 (18.6) 38 (11.5) 1.89(0.97–3.67) 1.85 (0.95–3.61)
SNP rs3772109 (T>C)
TT 33 (33.7) 104 (31.2) Reference -
TC 51 (52.0) 164 (49.2) 0.98 (0.59–1.62) 0.99 (0.60–1.65)
CC 14 (14.3) 65 (19.5) 0.68 (0.34–1.36) 0.69 (0.34–1.41)