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Table 3 Effect estimates (odds ratios) for spina bifida-affected pregnancies associated with maternal choline intake, CHKA SNP hCV1562388 (A>C), hCV1562393(C>G), PCYT1A SNPs rs939883 (T>A) and rs3772109 (T>C) genotypes. Breslow-Day test: P > 0.05. Lower 25%: total choline intake ≤ 289.93 mg/day. Higher 75 %: total choline intake > 513.24 mg/day.

From: CHKA and PCYT1Agene polymorphisms, choline intake and spina bifida risk in a California population

CHKA gene Cases Controls OR (95% CI)
SNP hCV1562388 (A>C)
Lower 25 percentile    Reference  
AA 17 35   
AC + CC 15 49 0.63 0.28–1.63
Higher 75 percentile    Reference  
AA 37 103   
AC + CC 31 148 0.58 0.34–1.00
SNP hCV1562393(C>G)
Lower 25 percentile    Reference  
CC 22 58   -
CG + GG 9 25 1.08 0.43–2.70
Higher 75 percentile    Reference  
CC 44 167   -
CG + GG 23 83 1.05 0.60–1.86
PCYT1A gene Cases Controls OR 95% CI
SNP rs939883 (T>A)
Lower 25 percentile    Reference  
TT 9 37   
TA 17 35 1.23 0.43–3.52
AA 7 11 1.66 0.41–3.52
Higher 75 percentile    Reference  
TT 26 95   
TA 31 126 0.90 0.50–1.61
AA 12 27 1.62 0.72–3.64
SNP rs3772109 (T>C)
Lower 25 percentile    Reference  
TT 9 27   
TC 17 40 1.28 0.50–3.28
CC 5 16 0.94 0.27–3.29
Higher 75 percentile    Reference  
TT 24 77   
TC 34 124 0.88 0.49–1.59
CC 10 49 0.59 0.25–1.37