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Table 3 Genes that were expected to be expressed in stria vascularis.

From: Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model

   

Slc26a4 +/+

Slc26a4 -/-

  

No.

Gene

Description

Intensity

P

Intensity

P

Fold

Direction

1

Slc12a1

Na+/2Cl-/K+ cotransporter

14,664

12/12

10,656

12/12

1.33

down

2

Atp1a1

Na+/K+ ATPase, alpha

7,276

9/15

5,440

9/15

2.06

down

3

Atp1b1

Na+/K+ ATPase, beta1

10,593

12/18

8,587

12/18

1.20

 

4

Atp1b2

Na+/K+ ATPase, beta2

8,057

6/6

5,984

6/6

1.41

down

5

Kcnq1

K+ channel, alpha

858

15/24

542

11/24

2.48

down

6

Kcne1

K+ channel, beta

9,042

6/6

3,490

6/6

2.60

down

7

Kcnma1

K+ channel, BK

270

10/18

159

9/18

1.72

down

8

Kcnk1

K+ channel

2,667

6/6

1,670

6/6

1.92

down

9

Slc26a4

Pendrin

1,136

3/3

619

3/3

1.84

down

10

Kcnj10

K+ channel

17,169

3/3

17,005

3/3

1.01

 

11

Car2

Carbonic anhydrase

9,139

3/3

9,167

3/3

1.00

 

12

Gjb2

Connexin 26

12,785

3/3

12,629

3/3

1.01

 

13

Gjb6

Connexin 30

15,257

3/3

13,060

3/3

1.17

 

14

Sod1

Superoxide dismutase

4,149

14/15

3,538

14/15

1.21

 

15

Cat

Catalase

3,520

6/6

4,686

6/6

1.12

 

16

Gpx1

Glutathione peroxidase

2,633

3/3

4,320

3/3

1.64

up

17

Gpx3

Glutathione peroxidase

12,526

3/3

9,898

3/3

1.27

 

18

Gpx4

Glutathione peroxidase

11,224

6/6

10,421

6/6

1.06

 

19

Tyr

Tyrosinase

3,520

6/6

4,686

6/6

1.16

 
  1. Genes that are expected to be expressed in marginal and spindle cells of stria vascularis (1–9) and genes that are expected to be expressed in intermediate and basal cells of stria vascularis (10–19) are listed. For parameters 'P', 'Fold' and 'Direction', see the Gene array section in Methods. Fold changes are given when a gene was called Present (P) in Slc26a4 +/- or Slc26a4 -/- samples in at least half of the available probes. The direction of the fold change is only given when it exceeded 1.30. Fold changes lower than 1.30 were not considered significant.