Table 1 Demographics in the different genotypes of the β2-adrenergic receptor.
Genotype | n* (% of all) | Age mean ± SD | BMI mean ± SD | Hypertension n (% of n*) | Diabetes n (% of n*) | Dyslipidemia n (% of n*) | CHD n (% of n*) | MI n (% of n*) |
|---|---|---|---|---|---|---|---|---|
All | 429 | 55.2 ± 10.7 | 31.1 ± 5.6 | 258 (60.1) | 74 (17.2) | 211 (49.2) | 55 (12.8) | 27 (6.3) |
Codon -47 | ||||||||
Cys/Cys | 131 (24.0) | 55.9 ± 11.3 | 30.8 ± 5.2 | 76 (58.0) | 23 (17.6) | 65 (49.6) | 16 (12.2) | 11 (8.4) |
Cys/Arg | 195 (45.2) | 55.1 ± 10.7 | 31.1 ± 6.0 | 119 (61.0) | 36 (18.5) | 91 (46.7) | 25 (12.8) | 6 (3.1) |
Arg/Arg | 103 (30.5) | 54.2 ± 9.7 | 31.5 ± 5.6 | 63 (61.2) | 15 (14.6) | 55 (53.4) | 14 (13.6) | 10 (9.7) |
P | 0.512 | 0.705 | 0.837 | 0.694 | 0.539 | 0.952 | 0.040 | |
Codon 16 | ||||||||
Arg/Arg | 59 (13.8) | 57.0 ± 9.9 | 31.6 ± 6.0 | 34 (57.6) | 12 (20.8) | 30 (50.8) | 6 (10.9) | 6 (10.2) |
Arg/Gly | 197 (45.9) | 54.0 ± 11.1 | 31.1 ± 6.0 | 121 (61.4) | 35 (17.8) | 95 (48.2) | 23 (11.7) | 7 (3.6) |
Gly/Gly | 173 (40.3) | 54.7 ± 10.5 | 31.0 ± 5.0 | 103 (59.5) | 27 (15.6) | 86 (49.7) | 26 (15.0) | 14 (8.1) |
P | 0.347 | 0.790 | 0.854 | 0.684 | 0.924 | 0.507 | 0.084 | |
Codon 27 | ||||||||
Gln/Gln | 109 (25.4) | 55.9 ± 11.0 | 31.5 ± 5.4 | 67 (61.5) | 23 (21.1) | 60 (55.0) | 16 (14.7) | 13 (11.9) |
Gln/Glu | 202 (47.1) | 56.0 ± 10.5 | 31.0 ± 6.0 | 117 (57.9) | 33 (16.3) | 88 (43.6) | 24 (11.9) | 7 (3.5) |
Glu/Glu | 118 (27.5) | 52.9 ± 10.5 | 30-9 ± 5.2 | 74 (62.7) | 18 (15.3) | 63 (53.4) | 15 (12.7) | 7 (5.9) |
P | 0.031 | 0.746 | 0.663 | 0.454 | 0.087 | 0.391 | 0.013 |