Risk factors and myocardial infarction in patients with obstructive sleep apnea: impact of β2-adrenergic receptor polymorphisms

Table 3 Risk factors, coronary heart disease and myocardial infarction in haplotypes of the β2-adrenergic receptor.

• Haplotype 1: T/C at position -47, A/G at position 16, C/G at position 27.
• haplotype 2: C/C at position -47, G/G at position 16, G/G at position 27.
• haplotype 3: T/C at position -47, G/G at position 16, C/G at position 27.
• haplotype 4: T/T at position -47, A/G at position 16, C/C at position 27.
• haplotype 5: T/T at position -47, A/A at position 16, C/C at position 27.
Distribution of cardiovascular risk factors, CHD and MI in the five most frequent statistical haplotypes of the three β2-adrenergic receptor polymorphisms. Comparisons between the haplotypes were performed with the χ² test. Haplotype 1, with heterozygosity in all three polymorphisms, showed a significant (P = 0.021) lower rate of MI [n = 113, MI = 2 (1.8%]) compared with the rest of the study group [n = 316, MI = 25 (7.9%)]. This corresponds to an odds ratio of 0.21. There were no additional significant relations between clinical diagnoses and the β2-adrenergic receptor haplotypes. Furthermore, no significant differences in blood pressure, heart rate or lipid levels, respectively, existed between the different haplotypes (results not shown). Significant P factor is shown in bold.
CHD, coronary heart disease; Hap., haplotype; MI, myocardial infarction.

ISSN: 1741-7015