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Table 1 Baseline characteristics of patients in acetaminophen and placebo groups

From: The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients – a multicenter randomized study

  Acetaminophen group (n = 308) Placebo group (n = 135) p-value*
Age:    
Mean ± SD 43 ± 9 44 ± 8 0.399
Range 18–72 20–65  
Male (%) 284 (92) 128 (95) 0.322
Ethnic Origin (%):    
Caucasian 156 (51) 68 (50) 0.830
Hispanic 45 (15) 22 (16)  
African Descent 49 (16) 16 (12)  
Native American 43 (14) 23 (17)  
Other 15 (5) 6 (4)  
Body Mass Index:    
Mean ± SD 25 ± 5 25 ± 4  
Range 15–55 17–39  
Breath alcohol level at presentation to detoxification site:    0.711
Mean ± SD 0.161 ± 0.093 0.157 ± 0.099  
Range 0.001–0.710 0.001–0.550  
Self-reported alcoholic (%) 301 (98) 133 (99) 0.729
Duration of most recent drinking binge:    
< 1 week 56 (18) 22 (16) 0.193
1–4 weeks 98 (32) 36 (27)  
> 1 month 154 (50) 76 (56)  
Not reported 0 (0) 1 (1)  
CAGE (no. of yes answers; mean ± SD) 3.3 ± 0.9 3.3 ± 0.9 0.645
Alanine aminotransferase:    
mg/dL 49 ± 38 47 ± 37 0.398
Range 4–189 8–175  
Aspartate aminotransferase:    
IU/L 55 ± 39 55 ± 38 0.650
Range 6–198 12–194  
International normalized ratio:    0.652
INR 0.96 ± 0.09 0.96 ± 0.09  
Range 0.79–1.40 0.80–1.30  
Albumin:    0.589
g/dl 3.94 ± 0.45 3.93 ± 0.37  
Range 2.1–4.8 2.8–4.0  
Total bilirubin:    
mg/dL 0.74 ± 0.53 0.68 ± 0.45 0.286
Range 0.1–4.1 0.1–2.8  
Gamma glutamyl transferase:    
IU/L 161 ± 308 168 ± 274 0.799
Range 9.0–3492 12.0–1893  
  1. *Standardized values based upon upper limit of normal were used to calculate p-values.
  2. Normal ranges for Denver and Seattle sites are as follows. Alanine aminotransferase: Denver, ALT 5–40 mg/dL male, 5–36 mg/dL female; Seattle, 0–50 IU/L and 2–60 IU/L male, 2–40 IU/L female. Aspartate aminotransferases: Denver, 9–36 IU/L; Seattle: 0–50 IU/L and 2–50 IU/L male, 2–35 IU/L female (both). International normalized ratio: Denver, 0.82–1.17; Seattle, 0.9–1.1. Total bilirubin: Denver, 0.2–1.2 mg/dL; Seattle: 0.1–1.2 mg/dL and 0.2–1.5 mg/dL male, 0.2–1.3 mg/dl female. Gamma glutamyl transferase: Denver, 6–50 IU/L; Seattle: 5–105 IU/L male, 2–98 IU/L female and 2–80 IU/L male, 2–60 IU/L female. Albumin: Denver, 3.4–5.5 g/dl; Seattle, 3.3–5.0 and 3.5–4.9 g/dl