Figure 2
Histomorphological analysis of diaphragm muscle from mdx mice treated with vehicle, prednisone, PG-87367 and PG-873637+prednisone for 3 months. Three-month-old mdx mice were treated by daily subcutaneous injection with the indicated compounds for 3 months and at the end of treatment, the diaphragms were removed and a histomorphological analysis performed. Time 0, 3 month old mdx mice before treatment. Vehicle, mdx mice treated for 3 months with vehicle. Prednisone, mdx mice treated for 3 months with 1 mg/kg of prednisone. PG-873637, mdx mice treated for 3 months with 30 ug/kg of PG-873637. PG-873637 + prednisone, mdx mice treated for 3 months with the combination of 30 ug/kg PG-873637 plus 1 mg/kg prednisone. The two photographs in each treatment group are from representative diaphragm sections from two different animals in each treatment group. All samples were hematoxylin and eosin stained.