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Table 4 Models used for analysis of the effects of statins on incidence of Parkinson's disease using the Cox proportional survival method. (A) Atorvastatin; (B) lovastatin; (C) simvastatin. Model 1 included an adjustment for the interaction between PD and age. Model 2 included adjustments for the interaction between PD, three disorders associated with increased risk of PD and neuroleptic use. Model 3 included adjustments for the interaction between dementia, the Charlson Index and neuroleptic use. For the purpose of analysis of interactions with the Charlson Index, subjects with a Charlson Index of 0 or 1 were compared with those with a Charlson Index of ≥2. Cox Survival Models for Incidence of Parkinson's Disease. A. Atorvastatin vs CV Comparator

From: Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

  Model 1 Model 2 Model 3
Variable HR p value 95% Confidence limits for HR HR p value 95% Confidence limits for HR HR p value 95% Confidence limits for HR
Atorvastatin 0.90 0.15 0.79 1.04 0.96 0.59 0.84 1.11 0.99 0.90 0.86 1.14
   Versus CV      1.05 <0.0001 1.05 1.06 1.05 <0.0001 1.05 1.06
   Age      1.00 0.97 0.90 1.12     
   Hypertension      1.18 <0.0001 1.09 1.27     
   CVD      1.12 0.0059 1.03 1.21     
   Diabetes      5.12 <0.0001 4.62 5.68 4.97 <0.0001 4.48 5.51
   Charlson Index          1.33 <0.0001 1.23 1.44
Lovastatin             
   Versus CV 1.09 0.15 0.97 1.22 1.06 0.33 0.95 1.18 1.09 0.13 0.98 1.22
   Age      1.05 <0.0001 1.04 1.06 1.05 <0.0001 1.04 1.06
   Hypertension      0.99 0.85 0.81 1.10     
   CVD      1.20 <0.0001 1.11 1.29     
   Diabetes      1.13 0.0001 1.05 1.23     
   Charlson Index      5.16 <0.0001 4.66 5.71 5.02 <0.0001 4.53 5.55
Simvastatin          1.32 <0.0001 1.22 1.43
   Versus CV             
   Age 0.50 <0.0001 0.47 0.53 0.50 <0.0001 0.47 0.53 0.50 <0.0001 0.49 0.55
   Hypertension      1.05 <0.0001 1.05 1.06 1.05 <0.0001 1.05 1.06
   CVD      0.97 0.42 0.89 1.05     
   Diabetes      1.21 <0.0001 1.14 1.28     
   Charlson Index      1.11 0.0012 1.04 1.18     
Atorvastatin      5.26 <0.0001 4.85 5.70 5.08 <0.0001 4.69 5.50
   Versus CV          1.44 <0.0001 1.36 1.53
  1. HR, hazard ratio, CVD, cardiovacular disease, CV, cardiovascular.
  2. Model 1 included an adjustment for the interaction between dementia and age; model 2 included adjustments for the interaction between dementia and three disorders associated with increased risk of dementia.; model 3 included adjustments for the interaction between dementia and the Charlson Index, which is an index that provides a broad assessment for the amount of chronic disease.