TY - JOUR AU - Briollais, Laurent AU - Wang, Yuanyuan AU - Rajendram, Isaac AU - Onay, Venus AU - Shi, Ellen AU - Knight, Julia AU - Ozcelik, Hilmi PY - 2007 DA - 2007/08/07 TI - Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario JO - BMC Medicine SP - 22 VL - 5 IS - 1 AB - There is growing evidence that gene-gene interactions are ubiquitous in determining the susceptibility to common human diseases. The investigation of such gene-gene interactions presents new statistical challenges for studies with relatively small sample sizes as the number of potential interactions in the genome can be large. Breast cancer provides a useful paradigm to study genetically complex diseases because commonly occurring single nucleotide polymorphisms (SNPs) may additively or synergistically disturb the system-wide communication of the cellular processes leading to cancer development. SN - 1741-7015 UR - https://doi.org/10.1186/1741-7015-5-22 DO - 10.1186/1741-7015-5-22 ID - Briollais2007 ER -