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Table 1 Two-way interactions detected by the three methods with a P-value less than 5%

From: Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario

Rank

LRM

CART

MDR

 

Interaction

P-value

Interaction

P-value

Interaction

P-value

1

XPD-[Lys751Gln]

IL10-[G(-1082)A]

0.013

XPD-[Lys751Gln]

IL10-[G(-1082)A]

0.006*

XPD-[Lys751Gln]

IL10-[G(-1082)A]

0.009*

2

COMT-[Met108/158Val]

CCND1-[Pro241Pro]

0.020

CYP17-[C(518)T]

BARD1-[Pro24Ser]

0.013

COMT-[Met108/158Val]

CCND1-[Pro241Pro]

0.019

3

TNFA-[G(-308)A]

p27-[Val109Gly]

0.046

  

BARD1-[Pro24Ser]

XPD-[Lys751Gln]

0.037

4

    

IL13-[Arg130Gln]

CYP17-[C(518)T]

0.037

  1. *Significant after Bonferroni correction for the number of tests performed in the second stage analysis.