Figure 1

Effect of HVJ-E/BLM combined with CDDP and body weight. (A) The effect of HVJ-E/BLM combined with CDDP treatment against CT-26 tumors. When tumors in the dorsa of BALB/c mice reached 5 mm in diameter, HVJ-E (5000 HAU, i.t.), HVJ-E/BLM (5000 HAU, i.t.), CDDP (i.p.), or CDDP (i.p.) plus HVJ-E/BLM (5000 HAU, i.t.) was administered. The tumor diameter was measured every 3 days. Results are expressed as the mean (n = 8 per group). Data are representative of each group. Two independent experiments were performed. CDDP and HVJ-E/BLM treated tumor growth was strongly suppressed compared with saline treated tumors (control). *p < 0.05. By contrast, no significant difference (NS) was seen between control and CDDP alone. Results were statistically analyzed using the Steel-Dwass test. (B) The body weight of each groups. Data are expressed as means ± SD. No significant difference was seen in all groups.