Changes in creatinine across all trials. A: Modified L'Abbé plot of change in creatinine from baseline to study endpoint in the control arm (x-axis) versus NAC treatment arm (y-axis) of each study. Studies are weighted by inverse variance (i.e. larger symbols represent larger studies with less variability). Open circles denote cluster 2 studies [10, 11, 14, 25]. B: Box plot of change in creatinine from baseline to study endpoint in the control arm and NAC treatment arm of each study. Boxes represent the 25th, 50th and 75th percentiles. Whiskers are 5th and 95th percentiles. Dashed lines show the mean of each group. Open squares denote cluster 2 studies.