Differences between treatment groups in Montgomery Åsberg Depression Rating Scale (MADRS) scores, in relation to equivalence. Schematic presentation. Horizontal bars indicate two-sided 95% confidence intervals (CIs). Blue tinted area indicates zone of equivalence. Bars a and b: The 95% CI of the difference in symptom change lies between the equivalence margins of -5 and 5 points difference; equivalence of both treatments is demonstrated. Bars f and h: The 95% CI of the difference in symptom change lies entirely to the left of zero; a statistical significant difference in favor of usual care + paroxetine is demonstrated.