|
PANSS
|
Abrupt (n= 29)
|
Gradual 1 (n= 34)
|
Gradual 2 (n= 31)
|
All Groups (n= 94)
|
Between-treatment p-valuea
|
|---|
|
Total
| | | | | |
|
Baseline
|
74.6 (± 10.6)
|
76.0 (± 12.3)
|
76.2 (± 11.6)
|
75.6 (± 11.5)
| |
|
Change
|
-7.5 (± 14.4)†
|
-4.9 (± 17.1)
|
-9.8 (± 15.1)‡
|
-7.3 (± 15.6)‡
|
0.1497
|
|
Positive
| | | | | |
|
Baseline
|
21.7 (± 4.2)
|
23.1 (± 5.2)
|
21.1 (± 5.5)
|
22.0 (± 5.1)
| |
|
Change
|
-3.4 (± 4.6)‡
|
-2.6 (± 6.4)*
|
-3.0 (± 4.9)†
|
-3.0 (± 5.4)‡
|
0.2009
|
|
Negative
| | | | | |
|
Baseline
|
17.9 (± 4.8)
|
18.1 (± 5.2)
|
19.5 (± 5.7)
|
18.5 (± 5.2)
| |
|
Change
|
-0.7 (± 6.0)
|
0.2 (± 6.2)
|
-2.2 (± 5.8)*
|
-0.9 (± 6.1)
|
0.2904
|
|
Anxiety/depression
| | | | | |
|
Baseline
|
11.1 (± 3.4)
|
10.3 (± 3.6)
|
10.9 (± 3.4)
|
10.7 (± 3.5)
| |
|
Change
|
-1.6 (± 3.6)*
|
-0.5 (± 3.6)
|
-2.2 (± 3.9)†
|
-1.4 (± 3.7)‡
|
0.618
|
-
aFrom an analysis of covariance (ANCOVA) model with treatment, site, and baseline value as factors.
- *p < 0.05, †p < 0.01, ‡p < 0.001 versus baseline (paired t-test).
