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Table 3 Predictive accuracy (area-under-the-curve) of kallikreins, with correction by repeated 10-fold cross-validation

From: A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden

Predictor

Laboratory Model

Clinical Model

 

Any cancer

High-grade cancer

Any cancer

High-grade cancer

Base model

0.680 (0.636, 0.727)

0.816 (0.741, 0.881)

0.724 (0.677, 0.771)

0.868 (0.795, 0.925)

Base model+Free PSA

0.762 (0.727, 0.807)

0.832 (0.780, 0.916)

0.779 (0.746, 0.828)

0.867 (0.830, 0.941)

Base model+Intact PSA

0.688 (0.651, 0.740)

0.798 (0.760, 0.892)

0.724 (0.687, 0.774)

0.853 (0.822, 0.930)

Base model+hK2

0.725 (0.686, 0.772)

0.826 (0.771, 0.902)

0.760 (0.725, 0.809)

0.864 (0.803, 0.933)

Full model

0.832 (0.804, 0.874)

0.870 (0.841, 0.937)

0.836 (0.810, 0.880)

0.903 (0.860, 0.960)

  1. The base model for the laboratory model includes age and total prostate specific antigen (PSA), and for the clinical model includes age, total PSA, and digital rectal examination result. The full model includes the base model plus free PSA, intact PSA, and human kallikrein 2 (hK2). Cancers with biopsy Gleason score 7 and higher were considered high grade. 95% confidence intervals are given in parentheses, and were calculated using bootstrap methods with 1000 replications.
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BMC Medicine

ISSN: 1741-7015

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