25 years of HIV-1 research – progress and perspectives

Table 1 Antiretroviral drugs approved by the US Food and Drug Administration

Nucleoside reverse transcriptase inhibitor	Non-nucleoside reverse transcriptase inhibitor	Protease inhibitor	Entry inhibitor
Zidovudine	Nevirapine	Saquinavir	Maraviroc
Didanosine	Delavirdine	Ritonavir
Zalcitabine	Efavirenz	Indinavir	Integrase inhibitor
Stavudine	Etravirine	Nelfinavir	Raltegravir
Lamivudine		Atazanavir
Abacavir		Fosamprenavir	Combinations
Tenofovir		Tipranavir	Six available, combining two or three drugs
Emtricitabine		Darunavir
			Fusion inhibitor
			Enfuvirtide (T-20)

Entry and fusion inhibitors prevent HIV-1 infection of cells; integrase inhibitor prevents integration of provirus into cellular chromosome.

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