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Table 2 Subjects are presented according to the method of ascertainment, with the number of unaffected relatives genotyped for LRRK2 mutations shown in parenthesis

From: The Gly2019Ser mutation in LRRK2is not fully penetrant in familial Parkinson's disease: the GenePD study

Ascertainment method Subjects (unaffected relatives) Families LRRK2 mutations (%) LRRK2 families (%)
Total familial Parkinson's disease cases and families studied 903 (58) 509 58 (6.4%) 31 (6.1%)
• Affected siblings 730 (37) 401 47 (6.4%) 24 (6.0%)
• Affected parent-offspring 141 (20) 88 11 (7.8%) 7 (8.0%)
• Other affected relatives 32 (1) 20 0 0
Randomly ascertained PD 126 126 6 (4.8%) 6 (4.8%)
Controls 197 197 0 0
  1. No controls or unaffected family members were determined to be LRRK2 carriers.