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Figure 1 | BMC Medicine

Figure 1

From: LRRK2in Parkinson's disease – drawing the curtain of penetrance: a commentary

Figure 1

Schematic view of the variable penetrance of the different known mutant genes and genetic risk factors involved in familial and sporadic Parkinson's disease illustrating current hypotheses on the impact of genetic modifiers in expressivity of the disease. The higher the penetrance of a certain genetic trait, the more likely a familial clustering of the disease is observed, while lower penetrance is associated more with sporadic occurrence of Parkinson's disease. The G2019S mutation in the LRRK2 gene falls in the middle of this spectrum and may require the impact from additional susceptibility factors for full penetrance.

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