Table 1 Distribution of valvular regurgitation at initial echocardiogram in 4825 women exposed to fenfluramine and/or dexfenfluramine
From: Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals
| Â | Ages | |||||||
|---|---|---|---|---|---|---|---|---|
|  | <20 (n = 25) | 20–29 (n = 386) | 30–39 (n = 900) | 40–49 (n = 1442) | 50–59 (n = 1279) | 60–69 (n = 610) | 70+ (n = 183) | All ages (n = 4825) |
Aortic regurgitation | Â | Â | Â | Â | Â | Â | Â | Â |
   none (%) | 96.0 | 85.8 | 75.4 | 65.4 | 59.5 | 59.8 | 53.6 | 66.3 |
   trace (%) | 4.0 | 10.1 | 14.7 | 17.6 | 19.9 | 20.7 | 29.5 | 17.8 |
   mild (%) | 0 | 3.1 | 7.8 | 11.2 | 13.4 | 12.8 | 11.5 | 10.7 |
   moderate (%) | 0 | 1.0 | 2.0 | 5.1 | 6.6 | 5.7 | 4.9 | 4.7 |
   severe (%) | 0 | 0 | 0.11 | 0.62 | 0.55 | 0.98 | 0.55 | 0.50 |
Mitral regurgitation | Â | Â | Â | Â | Â | Â | Â | Â |
   none (%) | 64.0 | 42.2 | 36.4 | 29.8 | 24.9 | 22.6 | 18.6 | 29.6 |
   trace (%) | 32.0 | 50.8 | 50.7 | 54.4 | 54.3 | 54.1 | 48.6 | 53.0 |
   mild (%) | 4.0 | 4.9 | 10.3 | 11.2 | 13.9 | 13.6 | 13.1 | 11.6 |
   moderate (%) | 0 | 1.8 | 2.2 | 4.2 | 5.5 | 8.7 | 15.3 | 4.9 |
   severe (%) | 0 | 0.26 | 0.33 | 0.49 | 1.5 | 0.98 | 4.4 | 0.91 |
Tricuspid regurgitation | Â | Â | Â | Â | Â | Â | Â | Â |
   none (%) | 56.0 | 22.8 | 24.4 | 22.8 | 21.1 | 18.4 | 15.3 | 22.0 |
   trace (%) | 28.0 | 63.5 | 60.3 | 62.1 | 60.0 | 62.1 | 60.1 | 61.1 |
   mild (%) | 16.0 | 11.9 | 12.6 | 12.1 | 12.9 | 11.5 | 12.6 | 12.3 |
   moderate (%) | 0 | 1.8 | 2.6 | 2.5 | 5.2 | 6.6 | 10.4 | 4.0 |
   severe (%) | 0 | 0 | 0.11 | 0.55 | 0.70 | 1.5 | 1.6 | 0.62 |