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Table 1 Distribution of valvular regurgitation at initial echocardiogram in 4825 women exposed to fenfluramine and/or dexfenfluramine

From: Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals

  Ages
  <20 (n = 25) 20–29 (n = 386) 30–39 (n = 900) 40–49 (n = 1442) 50–59 (n = 1279) 60–69 (n = 610) 70+ (n = 183) All ages (n = 4825)
Aortic regurgitation         
   none (%) 96.0 85.8 75.4 65.4 59.5 59.8 53.6 66.3
   trace (%) 4.0 10.1 14.7 17.6 19.9 20.7 29.5 17.8
   mild (%) 0 3.1 7.8 11.2 13.4 12.8 11.5 10.7
   moderate (%) 0 1.0 2.0 5.1 6.6 5.7 4.9 4.7
   severe (%) 0 0 0.11 0.62 0.55 0.98 0.55 0.50
Mitral regurgitation         
   none (%) 64.0 42.2 36.4 29.8 24.9 22.6 18.6 29.6
   trace (%) 32.0 50.8 50.7 54.4 54.3 54.1 48.6 53.0
   mild (%) 4.0 4.9 10.3 11.2 13.9 13.6 13.1 11.6
   moderate (%) 0 1.8 2.2 4.2 5.5 8.7 15.3 4.9
   severe (%) 0 0.26 0.33 0.49 1.5 0.98 4.4 0.91
Tricuspid regurgitation         
   none (%) 56.0 22.8 24.4 22.8 21.1 18.4 15.3 22.0
   trace (%) 28.0 63.5 60.3 62.1 60.0 62.1 60.1 61.1
   mild (%) 16.0 11.9 12.6 12.1 12.9 11.5 12.6 12.3
   moderate (%) 0 1.8 2.6 2.5 5.2 6.6 10.4 4.0
   severe (%) 0 0 0.11 0.55 0.70 1.5 1.6 0.62