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Table 1 CRABP1 was up-regulated in mutant C99I45F (Aβ42/Aβ40↑) only, whereas mutant C99V50F (Aβ42/Aβ40↓) showed no differential expression of CRABP1

From: Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Aβ42reduces their differentiation potential

Name

Fold change C99I45F/C99WT

Fold change C99V50F/C99WT

P-value

 

Transcriptomics

Proteomics

Transcriptomics

Proteomics

Transcriptomics

Proteomics

CRABP1

2.7

2.6

1.3

-1.1

0.123

0.032

NEF3

2.6

3.1

2.3

2.7

0.038

0.01

NEFL

2.2

2.3

2.2

2.5

0.032

0.004

INA

1.8

1.8

1.6

1.9

0.056

0.002

  1. Comparisons of both mutants with C99WT. The overlay of transcriptomics and proteomics revealed four differentially expressed transcripts and proteins respectively. Out of these four, only CRABP1 was differentially expressed in C99I45F whereas C99V50F showed no differential expression of CRABP1 (compared with C99WT). One-way analysis of variance (ANOVA) was performed for C99WT, C99I45F and C99V50F. CRABP1, cellular retinoic acid binding protein 1 (NCBI accession of the protein identified by proteomics: gi|48146151); NEF3, neurofilament 3 (gi|67678152); NEFL, neurofilament light polypeptide 68 kDa (gi|105990539); INA, internexin neuronal intermediate filament protein alpha (gi|14249342).
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BMC Medicine

ISSN: 1741-7015

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