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Table 1 Demographic, diagnostic, clinical and radiological features of human immunodeficiency virus (HIV)-infected and HIV-uninfected children being treated for tuberculosis.

From: Rifampin pharmacokinetics in children, with and without human immunodeficiency virus infection, hospitalized for the management of severe forms of tuberculosis

  Human immunodeficiency virus-infected
N= 21
Human immunodeficiency virus-uninfected
N= 33
Pvalue
Age (years) 3.73 4.05 0.68
Male sex 12 (57%) 16 (48%) 0.58
Culture of M. tuberculosis or acid-fast bacillus smear seen on microscopy1 10 (48%) 18 (60%) 0.16
Household tuberculosis contact 14 (67%) 23 (70%) 0.82
Mantoux test2    
≥ 10 mm 4 (20%) 30 (91%) <0.001
≥ 5 mm - -  
Clinical features    
Pulmonary tuberculosis 18 (86%) 27 (82%) 0.72
Tuberculous meningitis 7 (33%) 19 (58%) 0.16
Nutritional status    
Mass <3rd percentile for age 8 (38%) 13 (39%) >0.99
Kwashiorkor 6 (29%) 6 (18%) 0.50
Marasmus 8 (38%) 3 (9%) 0.014
Marasmic kwashiorkor 4 (19%) 3 (9%) 0.41
Radiological features    
Hilar adenopathy 11 (52%) 18 (55%) >0.99
Lobar opacification 9 (43%) 10 (30%) 0.39
Micronodular opacification 5 (24%) 7 (21%) >0.99
Cavitation 0 6 (18%) 0.072
Abdominal nodes3 5 (24%) 6 (18%) 0.73
  1. 1Culture and microscopy not carried out in three human immunodeficiency virus (HIV)-uninfected children.
  2. 2Mantoux test not read in one HIV-uninfected child.
  3. 3Abdominal nodes visualised on ultrasound.