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Table 1 Demographic, diagnostic, clinical and radiological features of human immunodeficiency virus (HIV)-infected and HIV-uninfected children being treated for tuberculosis.

From: Rifampin pharmacokinetics in children, with and without human immunodeficiency virus infection, hospitalized for the management of severe forms of tuberculosis

 

Human immunodeficiency virus-infected

N= 21

Human immunodeficiency virus-uninfected

N= 33

Pvalue

Age (years)

3.73

4.05

0.68

Male sex

12 (57%)

16 (48%)

0.58

Culture of M. tuberculosis or acid-fast bacillus smear seen on microscopy1

10 (48%)

18 (60%)

0.16

Household tuberculosis contact

14 (67%)

23 (70%)

0.82

Mantoux test2

   

≥ 10 mm

4 (20%)

30 (91%)

<0.001

≥ 5 mm

-

-

 

Clinical features

   

Pulmonary tuberculosis

18 (86%)

27 (82%)

0.72

Tuberculous meningitis

7 (33%)

19 (58%)

0.16

Nutritional status

   

Mass <3rd percentile for age

8 (38%)

13 (39%)

>0.99

Kwashiorkor

6 (29%)

6 (18%)

0.50

Marasmus

8 (38%)

3 (9%)

0.014

Marasmic kwashiorkor

4 (19%)

3 (9%)

0.41

Radiological features

   

Hilar adenopathy

11 (52%)

18 (55%)

>0.99

Lobar opacification

9 (43%)

10 (30%)

0.39

Micronodular opacification

5 (24%)

7 (21%)

>0.99

Cavitation

0

6 (18%)

0.072

Abdominal nodes3

5 (24%)

6 (18%)

0.73

  1. 1Culture and microscopy not carried out in three human immunodeficiency virus (HIV)-uninfected children.
  2. 2Mantoux test not read in one HIV-uninfected child.
  3. 3Abdominal nodes visualised on ultrasound.