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Table 1 Demographic and clinical data for the septic shock subclasses indentified in Figure 2.

From: Identification of pediatric septic shock subclasses based on genome-wide expression profiling

  Subclass A Subclass B Subclass C
Number of patients 28 45 25
Median age in years (IQR) 0.3 (0.1–2.7) 4.3 (1.9–7.3)1 2.0 (0.8–2.7)
Number of males/females 19/9 19/26 14/11
Number of deaths (%) 10 (36)2 5 (11) 3 (12)
Median pediatric risk of mortality (PRISM) score (IQR) 20.5 (12.5–32.5)2 15.0 (10.0–21.0) 15.0 (10.7–19.2)
Maximum number of organ failures (IQR)3 3 (3–4)2 2 (2–3) 2 (2–2)
Number with co-morbidity (%)4 10 (36) 20 (44) 11 (44)
Number with immune suppression (%)5 7 (25) 14 (31) 2 (8)
Number receiving hydrocortisone (%)6 8 (29) 22 (49)5 5(20)
Number with Gram-positive bacteria (%)7 11 (39)8 10 (22) 2 (8)
Number with Gram-negative bacteria (%) 3 (11) 9 (20) 8 (32)
Number with negative cultures (%) 11 (39) 24 (53) 10 (40)
  1. 1 P < 0.05 versus subclasses A and C, Mann-Whitney.2 P < 0.05 versus subclasses B and C, Chi-square.3Refers to the maximum number of organ failures during the initial 7 days of admission to the pediatric intensive care unit.4Refers to patients having any major diagnosis in addition to septic shock (for example, trauma, sickle cell disease, congenital heart disease, liver failure, and so on).5Refers to patients with immune deficiency secondary to an intrinsic documented defect of the immune system, or patients receiving immune-suppressive medications (for example, calcineurin inhibitors or high dose steroids).6For cardiovascular shock.7All bacterial culture data refer to samples obtained from bodily fluids that are normally sterile (that is, blood, urine, cerebral spinal fluid, broncho-alveolar lavage, and/or peritoneal fluid).8 P < 0.05 versus subclass C, Chi-square. IQR = intra-quartile range.