Identification of pediatric septic shock subclasses based on genome-wide expression profiling

Table 1 Demographic and clinical data for the septic shock subclasses indentified in Figure 2.

	Subclass A	Subclass B	Subclass C
Number of patients	28	45	25
Median age in years (IQR)	0.3 (0.1–2.7)	4.3 (1.9–7.3)¹	2.0 (0.8–2.7)
Number of males/females	19/9	19/26	14/11
Number of deaths (%)	10 (36)²	5 (11)	3 (12)
Median pediatric risk of mortality (PRISM) score (IQR)	20.5 (12.5–32.5)²	15.0 (10.0–21.0)	15.0 (10.7–19.2)
Maximum number of organ failures (IQR)³	3 (3–4)²	2 (2–3)	2 (2–2)
Number with co-morbidity (%)⁴	10 (36)	20 (44)	11 (44)
Number with immune suppression (%)⁵	7 (25)	14 (31)	2 (8)
Number receiving hydrocortisone (%)⁶	8 (29)	22 (49)⁵	5(20)
Number with Gram-positive bacteria (%)⁷	11 (39)⁸	10 (22)	2 (8)
Number with Gram-negative bacteria (%)	3 (11)	9 (20)	8 (32)
Number with negative cultures (%)	11 (39)	24 (53)	10 (40)

¹ P < 0.05 versus subclasses A and C, Mann-Whitney.² P < 0.05 versus subclasses B and C, Chi-square.³Refers to the maximum number of organ failures during the initial 7 days of admission to the pediatric intensive care unit.⁴Refers to patients having any major diagnosis in addition to septic shock (for example, trauma, sickle cell disease, congenital heart disease, liver failure, and so on).⁵Refers to patients with immune deficiency secondary to an intrinsic documented defect of the immune system, or patients receiving immune-suppressive medications (for example, calcineurin inhibitors or high dose steroids).⁶For cardiovascular shock.⁷All bacterial culture data refer to samples obtained from bodily fluids that are normally sterile (that is, blood, urine, cerebral spinal fluid, broncho-alveolar lavage, and/or peritoneal fluid).⁸ P < 0.05 versus subclass C, Chi-square. IQR = intra-quartile range.

ISSN: 1741-7015