From: Identification of pediatric septic shock subclasses based on genome-wide expression profiling
 | Pathway | Pvalue | Number of genes |
---|---|---|---|
CLUSTER 1 | Â | Â | Â |
 | Erythropoietin signaling | 2.0E-8 | 14 |
 | B cell receptor signaling | 2.6E-8 | 20 |
 | Leukocyte extravasation signaling | 2.8E-8 | 23 |
 | Triggering receptor expressed on myeloid cells signaling | 2.3E-7 | 12 |
 | Janus kinase (JAK)/signal transducers and activator of transcription (STAT) signaling | 2.8E-7 | 12 |
CLUSTER 2 | Â | Â | Â |
 | Interferon signaling | 8.7E-5 | 5 |
 | Erythropoietin signaling | 7.4E-4 | 6 |
 | Insulin receptor signaling | 1.0E-3 | 8 |
 | B cell receptor signaling | 2.3E-3 | 8 |
 | JAK/STAT signaling | 2.7E-3 | 5 |
CLUSTER 3 | Â | Â | Â |
 | Axon guidance signaling | 1.8E-6 | 38 |
 | Methane metabolism | 2.9E-3 | 4 |
 | Coagulation system | 1.9E-2 | 5 |
 | Calcium signaling | 2.0E-2 | 14 |
 | Glycine, serine, and threonine metabolism | 2.9E-2 | 7 |
CLUSTER 4 | Â | Â | Â |
 | One carbon pool by folate | 2.4E-3 | 3 |
 | Protein ubiquitination pathway | 2.4E-3 | 8 |
 | Interleukin-8 signaling | 2.1E-4 | 6 |
 | Glucocorticoid receptor signaling | 4.1E-2 | 7 |
 | Glycine, serine, and threonine metabolism | 5.5E-2 | 3 |
CLUSTER 5 | Â | Â | Â |
 | B cell receptor signaling | 1.2E-5 | 11 |
 | Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling | 6.9E-5 | 10 |
 | Retinoic acid receptor activation | 1.2E-3 | 9 |
 | Peroxisome proliferator-activated receptor (PPARα)/retinoid × receptor (RXRα) activation | 1.3E-3 | 9 |
 | PI3 kinase/Akt signaling | 2.0E-3 | 7 |
CLUSTER 6 | Â | Â | Â |
 | p38 mitogen-activated protein kinase (MAPK) signaling | 7.3E-5 | 10 |
 | Toll-like receptor signaling | 9.3E-4 | 6 |
 | PPARα/RXRα activation | 2.2E-3 | 11 |
 | Ephrin receptor signaling | 2.2E-3 | 11 |
 | Sphingolipid metabolism | 2.8E-3 | 6 |
CLUSTER 7 | Â | Â | Â |
 | Interleukin-4 signaling | 1.4E-2 | 4 |
 | Antigen presentation pathway | 1.5E-2 | 3 |
 | Glyoxylate and dicarboxylate metabolism | 3.3E-2 | 2 |
 | B cell receptor signaling | 5.2E-2 | 5 |
 | Citrate cycle | 6.9E-2 | 2 |
CLUSTER 8 | Â | Â | Â |
 | Epidermal growth factor signaling | 8.3E-3 | 4 |
 | Wnt/β-catenin signaling | 9.6E-3 | 8 |
 | Ceramide signaling | 1.3E-2 | 5 |
 | Epidermal growth factor (ERK)/MAPK signaling | 1.6E-2 | 8 |
 | Huntington's disease signaling | 1.8E-2 | 9 |
CLUSTER 9 | Â | Â | Â |
 | Death receptor signaling | 1.4E-5 | 11 |
 | B cell receptor signaling | 2.8E-5 | 17 |
 | Integrin signaling | 5.1E-5 | 20 |
 | Huntington's disease signaling | 7.0E-5 | 21 |
 | EGF signaling | 2.1E-4 | 8 |
CLUSTER 10 | Â | Â | Â |
 | T cell receptor signaling | 2.7E-7 | 9 |
 | Natural killer cell signaling | 5.4E-5 | 7 |
 | Chemokine signaling | 3.0E-2 | 3 |
 | NF-κB signaling | 4.4E-2 | 4 |
 | Stress-activated protein kinase/c-Jun NH2-terminal kinase signaling | 5.3E-2 | 3 |