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Table 2 Ingenuity Pathways Analysis-derived signaling pathways corresponding to the 10 individual K-means clusters depicted in Figure 4.

From: Identification of pediatric septic shock subclasses based on genome-wide expression profiling

 

Pathway

Pvalue

Number of genes

CLUSTER 1

   
 

Erythropoietin signaling

2.0E-8

14

 

B cell receptor signaling

2.6E-8

20

 

Leukocyte extravasation signaling

2.8E-8

23

 

Triggering receptor expressed on myeloid cells signaling

2.3E-7

12

 

Janus kinase (JAK)/signal transducers and activator of transcription (STAT) signaling

2.8E-7

12

CLUSTER 2

   
 

Interferon signaling

8.7E-5

5

 

Erythropoietin signaling

7.4E-4

6

 

Insulin receptor signaling

1.0E-3

8

 

B cell receptor signaling

2.3E-3

8

 

JAK/STAT signaling

2.7E-3

5

CLUSTER 3

   
 

Axon guidance signaling

1.8E-6

38

 

Methane metabolism

2.9E-3

4

 

Coagulation system

1.9E-2

5

 

Calcium signaling

2.0E-2

14

 

Glycine, serine, and threonine metabolism

2.9E-2

7

CLUSTER 4

   
 

One carbon pool by folate

2.4E-3

3

 

Protein ubiquitination pathway

2.4E-3

8

 

Interleukin-8 signaling

2.1E-4

6

 

Glucocorticoid receptor signaling

4.1E-2

7

 

Glycine, serine, and threonine metabolism

5.5E-2

3

CLUSTER 5

   
 

B cell receptor signaling

1.2E-5

11

 

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling

6.9E-5

10

 

Retinoic acid receptor activation

1.2E-3

9

 

Peroxisome proliferator-activated receptor (PPARα)/retinoid × receptor (RXRα) activation

1.3E-3

9

 

PI3 kinase/Akt signaling

2.0E-3

7

CLUSTER 6

   
 

p38 mitogen-activated protein kinase (MAPK) signaling

7.3E-5

10

 

Toll-like receptor signaling

9.3E-4

6

 

PPARα/RXRα activation

2.2E-3

11

 

Ephrin receptor signaling

2.2E-3

11

 

Sphingolipid metabolism

2.8E-3

6

CLUSTER 7

   
 

Interleukin-4 signaling

1.4E-2

4

 

Antigen presentation pathway

1.5E-2

3

 

Glyoxylate and dicarboxylate metabolism

3.3E-2

2

 

B cell receptor signaling

5.2E-2

5

 

Citrate cycle

6.9E-2

2

CLUSTER 8

   
 

Epidermal growth factor signaling

8.3E-3

4

 

Wnt/β-catenin signaling

9.6E-3

8

 

Ceramide signaling

1.3E-2

5

 

Epidermal growth factor (ERK)/MAPK signaling

1.6E-2

8

 

Huntington's disease signaling

1.8E-2

9

CLUSTER 9

   
 

Death receptor signaling

1.4E-5

11

 

B cell receptor signaling

2.8E-5

17

 

Integrin signaling

5.1E-5

20

 

Huntington's disease signaling

7.0E-5

21

 

EGF signaling

2.1E-4

8

CLUSTER 10

   
 

T cell receptor signaling

2.7E-7

9

 

Natural killer cell signaling

5.4E-5

7

 

Chemokine signaling

3.0E-2

3

 

NF-κB signaling

4.4E-2

4

 

Stress-activated protein kinase/c-Jun NH2-terminal kinase signaling

5.3E-2

3