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Table 2 Ingenuity Pathways Analysis-derived signaling pathways corresponding to the 10 individual K-means clusters depicted in Figure 4.

From: Identification of pediatric septic shock subclasses based on genome-wide expression profiling

  Pathway Pvalue Number of genes
CLUSTER 1    
  Erythropoietin signaling 2.0E-8 14
  B cell receptor signaling 2.6E-8 20
  Leukocyte extravasation signaling 2.8E-8 23
  Triggering receptor expressed on myeloid cells signaling 2.3E-7 12
  Janus kinase (JAK)/signal transducers and activator of transcription (STAT) signaling 2.8E-7 12
CLUSTER 2    
  Interferon signaling 8.7E-5 5
  Erythropoietin signaling 7.4E-4 6
  Insulin receptor signaling 1.0E-3 8
  B cell receptor signaling 2.3E-3 8
  JAK/STAT signaling 2.7E-3 5
CLUSTER 3    
  Axon guidance signaling 1.8E-6 38
  Methane metabolism 2.9E-3 4
  Coagulation system 1.9E-2 5
  Calcium signaling 2.0E-2 14
  Glycine, serine, and threonine metabolism 2.9E-2 7
CLUSTER 4    
  One carbon pool by folate 2.4E-3 3
  Protein ubiquitination pathway 2.4E-3 8
  Interleukin-8 signaling 2.1E-4 6
  Glucocorticoid receptor signaling 4.1E-2 7
  Glycine, serine, and threonine metabolism 5.5E-2 3
CLUSTER 5    
  B cell receptor signaling 1.2E-5 11
  Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling 6.9E-5 10
  Retinoic acid receptor activation 1.2E-3 9
  Peroxisome proliferator-activated receptor (PPARα)/retinoid × receptor (RXRα) activation 1.3E-3 9
  PI3 kinase/Akt signaling 2.0E-3 7
CLUSTER 6    
  p38 mitogen-activated protein kinase (MAPK) signaling 7.3E-5 10
  Toll-like receptor signaling 9.3E-4 6
  PPARα/RXRα activation 2.2E-3 11
  Ephrin receptor signaling 2.2E-3 11
  Sphingolipid metabolism 2.8E-3 6
CLUSTER 7    
  Interleukin-4 signaling 1.4E-2 4
  Antigen presentation pathway 1.5E-2 3
  Glyoxylate and dicarboxylate metabolism 3.3E-2 2
  B cell receptor signaling 5.2E-2 5
  Citrate cycle 6.9E-2 2
CLUSTER 8    
  Epidermal growth factor signaling 8.3E-3 4
  Wnt/β-catenin signaling 9.6E-3 8
  Ceramide signaling 1.3E-2 5
  Epidermal growth factor (ERK)/MAPK signaling 1.6E-2 8
  Huntington's disease signaling 1.8E-2 9
CLUSTER 9    
  Death receptor signaling 1.4E-5 11
  B cell receptor signaling 2.8E-5 17
  Integrin signaling 5.1E-5 20
  Huntington's disease signaling 7.0E-5 21
  EGF signaling 2.1E-4 8
CLUSTER 10    
  T cell receptor signaling 2.7E-7 9
  Natural killer cell signaling 5.4E-5 7
  Chemokine signaling 3.0E-2 3
  NF-κB signaling 4.4E-2 4
  Stress-activated protein kinase/c-Jun NH2-terminal kinase signaling 5.3E-2 3