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Table 29 Further sensitivity analyses for smoking-adjusted data. Effect of preferring estimates for current smokeless tobacco use to those for ever or unspecified smokeless tobacco use

From: Systematic review of the relation between smokeless tobacco and cancer in Europe and North America

     Heterogeneity
Cancer Analysisa N (nc)b Random-effects RR/OR (95% CI) χ2 P
Oropharyngeal Table 4 19 1.36 (1.04–1.77) 69.5 < 0.001
  Sensitivity (5) 1.42 (1.10–1.84) 51.1 < 0.001
Oesophageal Table 6 7 1.13 (0.95–1.36) 4.4 0.623
  Sensitivity (2) 1.11 (0.92–1.34) 4.1 0.665
Stomach Table 8 8 1.03 (0.88–1.20) 10.3 0.173
  Sensitivity (2) 1.01 (0.86–1.19) 10.4 0.165
Pancreatic Table 10 7 1.07 (0.71–1.60) 21.5 0.001
  Sensitivity (2) 1.22 (0.75–2.01) 23.1 < 0.001
Overall digestive Table 12 5 0.86 (0.59–1.25) 17.3 0.002
  Sensitivity (1) 0.85 (0.57–1.27) 17.3 0.002
Larynx Table 14 2 1.34 (0.61–2.95) 4.0 0.044
  Sensitivity (1) 1.45 (0.73–2.88) 2.5 0.116
Lung Table 16 6 0.99 (0.71–1.37) 28.7 < 0.001
  Sensitivity (3) 1.11 (0.73–1.69) 20.6 < 0.001
Prostate Table 18 4 1.29 (1.07–1.55) 1.2 0.764
  Sensitivity (0)    
Bladder Table 20 10 0.95 (0.71–1.29) 22.3 0.008
  Sensitivity (1) 0.94 (0.68–1.29) 23.7 0.005
Kidney Table 22 5 1.09 (0.69–1.71) 6.9 0.142
  Sensitivity (1) 1.07 (0.60–1.91) 9.6 0.048
Non-Hodgkin's lymphoma Table 24 3 1.35 (0.62–2.94) 9.5 0.009
  Sensitivity (0)    
Overall Table 27 7 0.98 (0.84–1.15) 27.1 < 0.001
  Sensitivity (1) 0.99 (0.83–1.17) 27.9 < 0.001
  1. a For each cancer the first line repeats the original results preferring ever or unspecified ST use shown in the Table indicated, while the second line presents the results of the sensitivity analysis preferring current ST use.
  2. b N is the number of estimates included in the original and sensitivity analyses; nc is the number of changed estimates. For each cancer, the identification numbers for the estimates (shown in the Table indicated) included in the sensitivity analysis are shown below, with those not used in the original analysis in italic.
  3. Oropharyngeal (Table 3): 2, 3, 4, 8, 11, 13, 18, 26, 35, 43, 48, 51, 55, 56, 58, 61, 70, 74, 75
  4. Oesophageal (Table 5): 3, 6, 10, 11, 19, 20, 23
  5. Stomach (Table 7): 1, 4, 7, 10, 14, 17, 19, 21
  6. Pancreatic (Table 9): 1, 3, 8, 11, 16, 18, 23
  7. Overall digestive (Table 11): 4, 5, 6, 7, 19
  8. Larynx (Table 13): 3, 14
  9. Lung (Table 15): 2, 3, 4, 9, 14, 20
  10. Prostate (Table 17): 1, 3, 5, 7
  11. Bladder (Table 19): 1, 4, 8, 9, 12, 17, 21, 22, 27, 31
  12. Kidney (Table 21): 1, 5, 13, 17, 19
  13. Non-Hodgkin's lymphoma (Table 23): 5, 13, 19
  14. Overall cancer (Table 26): 1, 2, 3, 4, 9, 10, 12
  15. CI = confidence interval; OR = odds ratio; RR = relative risk.