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Table 30 Summary of meta-analyses for smokeless tobacco use in Western populations

From: Systematic review of the relation between smokeless tobacco and cancer in Europe and North America

 

Overall data

Smoking-adjusted data

Never smokers

Cancer

n

RR/OR (95% CI)

n

RR/OR (95% CI)

n

RR/OR (95% CI)

Oropharyngeal (Table 4)

41

1.79 (1.36–2.36)

19

1.36 (1.04–1.77)

9

1.72 (1.01–2.94)

- (published since 1990)

18

1.28 (0.94–1.76)

14

1.00 (0.83–1.20)

7

1.24 (0.80–1.90)

Oesophageal (Table 6)

10

1.25 (1.03–1.51)

7

1.13 (0.95–1.36)

4

1.91 (1.15–3.17)

Stomach (Table 8)

9

1.03 (0.90–1.19)

8

1.03 (0.88–1.20)

4

1.27 (0.75–2.13)

Pancreatic (Table 10)

7

1.00 (0.68–1.47)

7

1.07 (0.71–1.60)

5

1.23 (0.66–2.31)

Any digestive (Table 12)

5

0.86 (0.59–1.25)

5

0.86 (0.59–1.25)

4

1.14 (0.99–1.33)

Larynx (Table 14)

5

1.43 (1.08–1.89)

2

1.34 (0.61–2.95)

0

-

Lung (Table 16)

9

0.96 (0.73–1.27)

6

0.99 (0.71–1.37)

5

1.34 (0.80–2.23)

Prostate (Table 18)

5

1.20 (1.03–1.40)

4

1.29 (1.07–1.55)

3

1.81 (0.76–4.30)

Bladder (Table 20)

14

1.00 (0.80–1.25)

10

0.95 (0.71–1.29)

6

1.10 (0.60–2.02)

Kidney (Table 22)

11

1.23 (0.86–1.76)

5

1.09 (0.69–1.71)

2

2.19 (0.63–7.70)

Non-Hodgkin's lymphoma (Table 24)

5

1.20 (0.83–1.75)

3

1.35 (0.62–2.95)

3

1.35 (0.62–2.95)

Overall cancer (Table 27)

7

0.98 (0.84–1.15)

7

0.98 (0.84–1.15)

6

1.10 (1.02–1.19)

  1. n = number of estimates included in meta-analyses.
  2. RR/OR = combined random-effects estimate based on RRs or ORs.
  3. CI = confidence interval; OR = odds ratio; RR = relative risk.